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KMID : 0370219960400010090
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Yakhak Hoeji
1996 Volume.40 No. 1 p.90 ~ p.94
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The Evaluation of in Vivo Antifungal Activities of 6-[(N-4-Fluorophenyl)amino]-7-Chloro-5,8-Quinolinedione
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박윤미/Park YM
김희정/김도희/이인경/김동현/유충규/Kim HJ/Kim DH/Lee IK/Kim DH/Ryu CK
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Abstract
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6-[(N-4-Fluorophenyl)amino]-7-chloro-5,8-quinolinedione(RCK3) was tested for antifungal activities, in vivo, against Candida albicans. RCK3 was compared with ketoconazole and fluconazole in the treatment of systemic infection with Candida albicans in normal mice. The therapeutic potential of RCK3 had been assessed by evaluating their activities (survival rate) against systemic infections in normal mice. RCK3 had ED50, 8.78 +/- 0.18mg/kg but ketoconazole and fluconazole had ED50, 8.00 +/- 0.73, 10.00 +/- 0.43mg/kg respectively. Intraperitoneally administered RCK3 at the ED50, 8.78mg/kg for 7 days and 14 days reduced Candida albicans colony count in the kidneys and livers as well as ketoconazole and fluconazole at these ED50, 8.00 and 10.00mg/kg. And administered RCK3 at the ED50 for 14 days improved survival rates better than ketoconazole.
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